SIMBA - explore the behavior of your favorite gene or sets of genes
The SIMBA yeast site allows interactive exploration of a large scale compendium of data from diverse high throughput experiments.
SIMBA's algorithm divides genes and properties (usually one time point or condition in an experiment such a DNA microarray) into Bi- clusters ("bics") composed of genes and properties such that the genes behave similarly in that group of conditions. Bics may overlap (in genes, conditions, or both), and a gene may be present in several bics, as it may be similar to one group of genes under conditions A-G and to a different set of genes under conditions H-M. Properties may be anything obtainable from genome-wide experiments: level of RNA expression, does or does not interact physically, does or does not interact genetically, is it or is it not resistant/sensitive to a certain drug, etc.